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本文用γ-谷氨酰转肽酶(γ-GTP)酶组织化学法检测了30例胃癌、21例胃粘膜不典型增生、17例肠上皮化生组织中γ-GTP活性。20例正常胃粘膜γ-GTP活性均呈阴性,但是30例胃癌组织中γ-GTP阳性率为93％,其中,高分化与中分化腺癌的γ-GTP阳性率达94％,未分化癌的阳性率为80％,视为癌前期病变的胃粘膜不典型增生和肠上皮化生组织中γ-GTP阳性率分别达95％和94％。可见,γ-GTP酶组织化学检测对胃癌及胃癌前期病变组织的早期诊断提供了比较敏感的组织化学指标。
The γ-GTP activity in 30 cases of gastric cancer, 21 cases of gastric dysplasia, and 17 cases of intestinal metaplasia was detected by gamma-glutamyl transpeptidase ([gamma]-GTP) histochemical method. The activity of γ-GTP was negative in 20 cases of normal gastric mucosa, but the positive rate of γ-GTP in 30 cases of gastric cancer was 93%. Among them, the positive rate of γ-GTP in highly differentiated and moderately differentiated adenocarcinoma was 94%. The positive rate was 80%. The positive rates of γ-GTP in gastric mucosal dysplasia and intestinal metaplasia that were considered precancerous lesions were 95% and 94%, respectively. Visible, γ-GTP enzyme histochemical detection of gastric cancer and gastric precancerous lesions provide a more sensitive tissue and chemical indicators.