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近年报道某些萜类能增强药物透皮作用,在许多天然的萜类中萜的氧化物如土荆芥油,7-氧二环庚烷及桉叶油等特别有效,应进一步研究。α-甜没药萜醇(α-BIS)是一单环不饱和叔倍半萜,它可以由天然原料提取(春黄菊精油,含(—)α-甜没药萜醇50％以上)或可合成制备(±)-α-甜没药萜醇。其大鼠口服LD_(50)>5g/kg,对皮肤无刺激性(兔),已证明其具有抗炎作用及防止皮肤受刺激。光学活性(-)萜为药理活性化合物。常用于皮肤及口腔保健用品,春黄菊浸膏用于嗽口剂、滴剂和油膏等。
In recent years, some terpenes have been reported to enhance the transdermal effects of drugs. In many natural terpenes, terpene oxides such as earth oil, 7-oxybicycloheptane and eucalyptus oil are particularly effective and should be further studied. α-Bisabolin (α-BIS) is a monocyclic unsaturated tertiary sesquiterpenoid that can be extracted from natural sources (Camomile essential oil containing more than 50% of (-)α-saccharinol) or The (±)-α-saccharinol can be synthesized and prepared. The rats had an oral LD_(50) of >5 g/kg, which was non-irritating to the skin (rabbit) and proved to have anti-inflammatory effects and prevent skin irritation. Optically active (-) quinones are pharmacologically active compounds. Commonly used in skin and oral health products, chamomile extract is used in mouthwash, drops and ointments.