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为了观察克洛曲在慢性癌痛病人中的疗效，采用多中心、双盲双模拟、自身交叉对照研究的方法，比较了克洛曲片、曲马多胶囊和安慰剂对１０８例中、重度癌痛的镇痛效果。结果表明克洛曲片的总有效率为８８．０％，明显高于曲马多胶囊的７２．２％（Ｐ＜０．０１）和安慰剂的３５．２％（Ｐ＜０．００１）；克洛曲片的缓解时间明显延长（Ｐ＜０．０１）；克洛曲片的药物不良反应的发生率与曲马多胶囊相似，但便秘的发生率明显低于曲马多胶囊（Ｐ＜０．０５）。克洛曲片对中、重度癌痛的镇痛效果确切，安全性较大。文章还对镇痛药临床研究的策略方法及安慰剂效应进行了详细的讨论。
In order to observe the curative effect of clenbuterol in patients with chronic cancer pain, a multicenter, double-blind, double-dummy, self-controlled crossover study was conducted to compare the effects of clenbuterol, tramadol and placebo on 108 patients with moderate to severe Analgesic effect of cancer pain. The results showed that the total effective rate of clobetaine was 88.0%, significantly higher than that of tramadol 72.2% (P <0.01) and placebo (P <0.001) (P <0.01). The incidence of adverse drug reactions was similar to that of tramadol, but the incidence of constipation was significantly lower than that of tramadol (P <0.01) <0.05). Cleopatra in the right, severe analgesic pain relief effect is exact, more secure. The article also discussed in detail the strategy and placebo effect of analgesic clinical research.