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目的 :通过对极低出生体重(very low birth weight,VLBW)患儿血清的可溶性晚期糖基化终产物受体(soluble receptor for advanced glycation end products,sRAGE)、内源性分泌型RAGE(endogenoussecretory RAGE,esRAGE)、肺表面活性蛋白D(surfactant protein D,SP-D)、Clara细胞蛋白16(clara cell 16 k D protein,CC-16)等血清标志物水平与支气管肺发育不良(bronchopulmonary dysplasia,BPD)的相关性研究,以期找到早期评估BPD发生可能性及严重程度的敏感指标。方法 :选取极低出生体重儿60例,在生后48 h内留取血清,ELISA法测定sRAGE、esRAGE、SP-D、CC-16等血清标志物水平,同时记录患儿BPD发生情况及程度,统计学分析血清学指标与BPD发生及程度的相关性。结果 :1与非BPD组患儿相比,BPD组患儿血清sRAGE、esRAGE水平明显增高(P均<0.01);而SP-D、CC-16水平差异无统计学意义(P均>0.05);2BPD患儿中,sRAGE、esRAGE在轻度、中度及重度组间差异也有统计学意义;3血清sRAGE、esRAGE水平与患儿胎龄没有相关性。结论:血清sRAGE、esRAGE可以作为VLBW患儿发生BPD及严重程度的一个早期评估指标。
OBJECTIVE: To investigate the effect of soluble receptor for advanced glycation end products (sRAGE), endogenous secretory RAGE (RAGE) in children with very low birth weight (VLBW) , esRAGE), surfactant protein D (SP-D) and clara cell 16 k D protein (CC-16) were compared with bronchopulmonary dysplasia ) In order to find the early assessment of the possibility of BPD and severity of sensitive indicators. Methods: Sixty children with very low birth weight were enrolled in this study. Serum samples were collected within 48 hours after birth. The serum levels of sRAGE, esRAGE, SP-D and CC-16 were measured by ELISA. The incidence and extent of BPD in children were also recorded , Statistical analysis of serological indicators and BPD occurrence and extent of correlation. Results: Compared with non-BPD group, the levels of sRAGE and esRAGE in children with BPD were significantly increased (all P <0.01), while the levels of SP-D and CC-16 in children with BPD were not significantly different (all P> 0.05) There was also a significant difference in sRAGE and esRAGE among mild, moderate and severe groups in children with 2BPD; 3 There was no correlation between sRAGE and esRAGE levels in children with gestational age. Conclusion: Serum sRAGE and esRAGE can be used as an early assessment of BPD and severity in children with VLBW.