表皮生长因子受体抑制剂(epidermal growth factor receptor inhibitors,EGFRIs )已作为多种晚期肿瘤的一线治疗药物,但常引起各种皮肤不良反应,其引起的皮肤不良反应的相关发生机制包括角质形成细胞增殖、分化、黏附、迁移、凋亡的改变,皮肤屏障的破坏,炎症反应及皮肤光敏性的增加.“,”Epidermal growth factor receptor inhibitors ( EGFRIs) have been used as first-line therapies for a variety of advanced cancers,which,however,often result in various cutaneous adverse reactions. The mechanisms of EGFRIs-related cutaneous adverse reactions include alterations of keratinocyte proliferation,differentiation,adhesion,migration and apoptosis, destruction of the skin barrier, enhanced inflammatory response and photosensitivity to ultraviolet radiation.