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目的对比研究安全留置针和中心静脉置管2种乳腺癌患者化疗静脉给药途径的应用情况,为乳腺癌患者化疗静脉给药途径的选择提供理论依据。方法取本科2013年1月~2014年12月行表阿霉素+多西他赛(以下简称TA)方案化疗的乳腺癌患者108例,随机分为实验组和对照组各54例,对照组应用安全留置针予以外周静脉穿刺输液,实验组应用中心静脉置管输液,对比2组患者化疗药物渗漏出现的并发症、导管留置时间、对日常生活的影响等。结果对照组化疗药物渗漏导致并发症11例,导管留置时间为1~5d,对生活影响较大,实验组患者未发生化疗药物外渗及并发症,导管留置时间3~44d,平均23d,2组比较差异有统计学意义(P<0.05,对日常生活影响较小。2组比较,差异有统计学意义(P<0.05)。结论研究表明,采用中心静脉置管给药有效降低化疗药物泄露及并发症发生的概率,导管留置时间较长,对日常生活影响较小,值得在临床乳腺癌化疗患者中推广。
Objective To compare the application of intravenous chemotherapy in two kinds of breast cancer patients with safety indwelling needles and central venous catheterization, and to provide a theoretical basis for the selection of chemotherapy intravenous route of breast cancer patients. Methods 108 patients with breast cancer undergoing chemotherapy with epirubicin plus docetaxel (TA) from January 2013 to December 2014 were randomly divided into experimental group and control group (n = 54), and control group The application of safety indwelling needle to peripheral venous puncture infusion, experimental group application of central venous catheter infusion, compared with two groups of patients with chemotherapy drug leakage complications, catheter indwelling time, impact on daily life. Results In the control group, 11 cases of complications caused by leakage of chemotherapy drugs and 1 ~ 5 days of indwelling catheters had a significant impact on life. Patients in the experimental group did not have chemotherapy drug extravasation and complications. The catheter indwelling time was 3 to 44 days (mean, 23 days, The difference between the two groups was statistically significant (P <0.05, less impact on daily life .2 group comparison, the difference was statistically significant (P <0.05) .Conclusion The study shows that the use of central venous catheter to effectively reduce chemotherapy drugs Leakage and complications of the probability of catheter indwelling longer, less impact on daily life, it is worth in clinical chemotherapy in patients with breast cancer promotion.