论文部分内容阅读
芎归滴丸急性毒性试验，采用ICR系小鼠，ig给药LD50为1716.88mg／kg体重，ip给药LD50为526．9mg／kg体重，死亡动物的内脏肉眼未见异常改变；长期毒性试验，Wistar大鼠ig剂量为85．5、42．75、21．37mg／kg·d（人用量的50、25及12．5倍），共计给药90d，对大鼠一般情况的观察和对大鼠脏器系数、血象、肝肾功能、血糖的影响以及组织学研究（系统尸检和病理组织学）与对照组相比无显著差异，脏器系数比值正常，未发现毒性反应。
In the acute toxicity test of Zigui Pills, ICR mice were used, ig50 for ig was 1716.88 mg/kg body weight, and ip dose for LD50 was 526.9 mg/kg body weight. There was no abnormal change in the visceral eyes of dead animals; long-term toxicity test The ig doses of Wistar rats were 85.5, 42.75, and 21.37 mg/kg·d (50, 25, and 12.5 times of the human dose). The total dose was 90 days, and the general conditions of the rats were observed and compared. The effects of organ coefficient, blood, liver and kidney function, and blood glucose in rats and histological studies (system necropsy and histopathology) were not significantly different from those in the control group. The ratio of organ coefficient was normal, and no toxic reaction was found.