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目的 研究亚胺培南在严重烧伤早期家兔痂下组织液中的药代动力学变化。方法 烧伤组 :烧伤早期家兔 ;对照组 :正常非烧伤家兔于 2 0min内iv10 0mg泰能后 ,用微生物琼脂打孔扩散法测定痂下组织液和血浆中亚胺培南的浓度 ,利用 3P87软件计算其相关药代动力学参数 ,采用SPSS8.0软件包进行统计学处理。结果 与对照组相比 ,烧伤组亚胺培南药代动力学参数发生显著改变。烧伤组血浆和痂下组织液中亚胺培南T1/ 2 明显延长 ,分别为血浆 (1.4 9± 0 .2 1)h、痂下组织液 (2 .4 9± 0 .4 3)h ;对照组血浆 (1.10± 0 .18)h ;亚胺培南在痂下组织液中在用药后 1h即可以检测到 ,有效浓度可维持 6～ 8h。结论 亚胺培南在烧伤早期痂下组织液和血浆中T1/ 2 明显延长 ,其在痂下组织液中形成抗生素保护屏障 ,有效地防止创面细菌的侵袭性感染
Objective To study the pharmacokinetics of imipenem in tissue fluid of scab in rabbits with severe burn early. Methods Burns group: rabbits in early burn group; control group: normal non-burn rabbits in 10min iv10 0mg Thai energy, the use of microbial agar diffusion method to determine the subcutaneous tissue fluid and plasma imipenem concentration, the use of 3P87 The software calculated its related pharmacokinetic parameters and used SPSS8.0 software package for statistical analysis. Results Compared with the control group, the pharmacokinetic parameters of imipenem in burn group changed significantly. The imipenem T1 / 2 in the plasma of the burn group and subcutaneous tissue fluid were significantly prolonged (1.4 9 ± 0.21 h) and tissue fluid (2.49 ± 0.43 h) in the control group Plasma (1.10 ± 0.18) h; Imipenem can be detected in tissue fluid under the scab at 1h after treatment, and the effective concentration can be maintained for 6 ~ 8h. Conclusion Imipenem significantly prolonged the T1 / 2 in the sub-scab tissue fluid and plasma in the early stage of burn, and formed an antibiotic protective barrier in the tissue fluid below the scab to effectively prevent the invasive infection of wound bacteria