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测定９６名镍作业工人血清硒（Ｓｅ）和丙二醛（ＭＤＡ）的含量分别为１．２２±０．２３和４．７６±０．８８μｍｏｌ／Ｌ，与地区对照组（２５名非镍作业人员）的结果（分别为１．４４±０．１９和３．０６±０．７１μｍｏｌ／Ｌ）相比，血清Ｓｅ水平降低，ＭＤＡ含量显著增高，提示镍对作业工人的脂质过氧化（ＬＰＯ）可能有损伤作用；将镍作业工人分为补硒组和平行对照组观察，结果补硒组在补硒后６和１２个月时血清Ｓｅ水平分别增至１．３２±０．１４和１．６２±０．１５μｍｏｌ／Ｌ，ＭＤＡ含量降至３．９１±０．４７和３．３４±０．５２μｍｏｌ／Ｌ，而平行对照组无明显变化，表明补硒对镍致作业工人的ＬＰＯ损伤作用有较好的拮抗或防护效果。
The serum selenium (Se) and malondialdehyde (MDA) levels of 96 nickel workers were determined to be 1.22 ± 0.23 and 4.76 ± 0.88 μmol / L, respectively, in comparison with the regional control group (25 non-nickel jobs (1.44 ± 0.19 and 3.06 ± 0.71 μmol / L, respectively), serum Se levels decreased and MDA content increased significantly, suggesting that nickel may be associated with lipid peroxidation (LPO ) Were divided into two groups: selenium group and parallel control group. Se levels of selenium group increased to 1.32 ± 0.14 and 1, 6 and 12 months after selenium supplementation .62 ± 0.15μmol / L, MDA content decreased to 3.91 ± 0.47 and 3.34 ± 0.52μmol / L, while no significant changes in the parallel control group, indicating that nickel supplementation caused LPO injury workers The role of a better antagonistic or protective effect.