论文部分内容阅读
AIM:To observe the expression of vascula r endothelial growth factor(VEGF)and Factor VIII related antigen(FVIII-R Ag )in rats brain tissue in the bor-der zone of the hematoma,and explore the relationship between the expres-sion of VEGF and the brain angionesis after intracerebral hmorrhage(ICH).METHODS:Rat of model of ICH was induced by inje ction of collagenase physiological saline into the right caudate nucleus.The immunohistoch emical methods were performed by using diff erent antisera of VEGF and FVIII-R Ag in serial sections of rats brain at 12h,1d,3d and 7d after ICH respec-tively.RESULTS:T he amount of VEGF positive cells was markedly in-creased,and reached the highest at 7th day in the border zone after ICG(P<0.01),but there were no significant diffe rence among the mean value of A of cells at different time points(P>0.05).Compared with the controls,both the FVIII-R Ag positive endothelial cells and the A of cells were signific antly different in experimental ICH goups after 1day.CONCLUSION:The up-regulated expression of VEGF might i nduce proliferation of endothelial cell and angiogenesis in the border zone a fter ICH in rats.
AIM: To observe the expression of vascula endothelial growth factor (VEGF) and Factor VIII related antigen (FVIII-R Ag) in rats brain tissue in the bor-der zone of the hematoma, and explore the relationship between the expres-sion of VEGF and the brain angionesis after intracerebral intramorrebral hemorrhage (ICH). METHODS: Rat of model of ICH was induced by in jection of collagenase physiological saline into the right caudate nucleus. The immunohistochmical methods were performed by using diffrent antisera of VEGF and FVIII- R Ag in serial sections of rats brain at 12h, 1d, 3d and 7d after ICH respec- tively .RESULTS: T he amount of VEGF positive cells was markedly in-creased, and reached the highest at 7th day in the border zone after ICG (P <0.01), but there were no significant diffe rence among the mean value of A of cells at different time points (P> 0.05). Compared with the controls, both the FVIII-R Ag positive endothelial cells and the A of cells were significantly different in experimental ICH goups after 1 day. CONCLUSION: The up-regulated expression of VEGF might i nduce proliferation of endothelial cell and angiogenesis in the border zone a fter ICH in rats.