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肾内阻力指数(RI)升高与肾移植术后移植物及受者长期存活率下降相关。本研究在肾移植术后病情稳定的患者中进行横断面调查,以研究内皮损伤、全身性炎症反应、动脉硬化性损害、左室重构等肾外因素是否影响移植肾RI。本研究共纳入174例肾移植受者,平均移植术后(8.4±1.8)年。检测心电图、颈动脉超声(内膜中层厚度)、脉搏波速及移植肾多普勒;测定炎症标志物、黏附分子和血浆氨基末端前体B型脑钠肽(NT-proBNP)浓度。依据RI值四分位数将患者分为4组(Q1:RI≤0.68,Q2:RI=0.69~0.72,Q3:RI=0.73~0.76,Q4:RI≥0.77)。研究结果显示,各组患者间除年龄以外的人口结构、人体测量参
Increased intrarenal resistance index (RI) is associated with decreased long-term graft survival in recipients after kidney transplantation. In this study, a cross-sectional investigation was performed in patients with stable disease after kidney transplantation to investigate whether renal factors such as endothelial injury, systemic inflammatory response, arteriosclerotic lesions, and left ventricular remodeling affect graft RI. A total of 174 renal transplant recipients were enrolled in this study, with a mean of (8.4 ± 1.8) years after transplantation. The electrocardiogram, carotid artery ultrasonography (intima-media thickness), pulse wave velocity and Doppler of renal grafts were detected. The levels of inflammatory markers, adhesion molecules and plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured. Patients were divided into 4 groups according to RI quartile (Q1: RI≤0.68, Q2: RI = 0.69 ~ 0.72, Q3: RI = 0.73 ~ 0.76, Q4: RI≥0.77). The results of the study show that in addition to the age of the population structure between the various groups of patients, the human body measured parameters