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目的 :探讨系统性红斑狼疮 (SLE)与妊娠、妊娠结局的关系。方法 :将SLE患者妊娠前后系统性红斑狼疮疾病活动性用SCEDAI法进行病情评估 ,比较其妊娠结果及疼痛活动性变化。结果 :SLE患者妊娠后系统性红斑狼疮疾病活动指数 (SLEDAI)升高 ,且SLEDAI评分越高 ,活产率越低。但静止期病人妊娠活产率高于活动期病人 (P =0 .0 0 9)。结论 :SLE造成异常妊娠并降低妊娠活产率 ,妊娠后SLE趋向于加重 ,在孕前对SLE患者进行SLEDAI评分并以此预测SLE患者妊娠结局 ,对SLE患者的生育有指导意义。
Objective: To investigate the relationship between systemic lupus erythematosus (SLE) and pregnancy and pregnancy outcome. Methods: The SLE patients with systemic lupus erythematosus before and after pregnancy disease activity by SCEDAI method for the assessment of the disease, compared with the pregnancy results and changes in pain activity. Results: SLE patients with systemic lupus erythematosus disease activity index (SLEDAI) after pregnancy increased, and the higher the SLEDAI score, the lower the live birth rate. However, the rate of live births in quiescent patients was higher than that in active patients (P = 0.090). CONCLUSIONS: SLE causes abnormal pregnancy and reduces the pregnancy live birth rate. SLE tends to aggravate after pregnancy. SLEDAI score is used to predict the pregnancy outcome of SLE patients before pregnancy, which has guiding significance for the fertility of SLE patients.