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研究证实细胞周期调控异常是肿瘤发生发展的内在原因[1]。ｐ21ＷＡＦ1/ＣＩＰ1和ｐ53是细胞周期调控的重要的负性调控因子。本实验以喉正常粘膜、喉粘膜不典型增生病变和喉癌为研究对象,采用免疫组化方法检测两种基因蛋白产物,观察在喉癌癌变过程中变化及相互关系。1 材料和方
Study confirmed that abnormal cell cycle control is the underlying cause of tumor development [1]. p21WAF1 / CIP1 and p53 are important negative regulators of cell cycle regulation. In this study, normal laryngeal mucosa, laryngeal mucosa atypical hyperplasia lesions and laryngeal cancer were studied. Immunohistochemistry was used to detect the expression of two kinds of gene products to observe the changes and correlations in carcinogenesis of laryngeal carcinoma. 1 material and side