论文部分内容阅读
目的探讨子宫内膜异位症患者采用红藤方治疗的临床疗效及血清MMP-9、TIMP-1及其比值的变化。方法经腹腔镜手术确诊为子宫内膜异位症的患者90例随机分为3组即红藤方组、米非司酮组和对照组,观察3组的临床疗效,并于术前及药物治疗3月后分别测定血清MMP-9和TIMP-1水平。结果与对照组比较,红藤方组和米非司酮组总有效率明显提高(P<0.05),且后2者治疗后MMP-9水平明显降低,TIMP-1水平显著提高,与前者相比差异均具有统计学意义(P<0.01)。MMP-9/TIMP-1比值3组治疗前后均显著降低,且治疗后红藤方组和米非司酮组与对照组比较下降更明显,差异具有统计学意义(P<0.05)。结论红藤方可能通过调节MMP-9/TIMP-1的平衡而纠正盆腔内环境,有效改善子宫内膜异位症患者的临床症状。
Objective To investigate the clinical efficacy and the changes of serum MMP-9, TIMP-1 and its ratio in patients with endometriosis treated with Red Teng Fang. Methods 90 cases of endometriosis diagnosed by laparoscopic surgery were randomly divided into three groups, ie, Hongtufang group, mifepristone group and control group. The clinical efficacy was observed in 3 groups. Serum levels of MMP-9 and TIMP-1 were measured after 3 months of treatment. Results Compared with the control group, the total effective rate was significantly increased (P <0.05), and the levels of MMP-9 and TIMP-1 in the latter two groups were significantly higher than those in the control group The differences were statistically significant (P <0.01). The ratio of MMP-9 / TIMP-1 in three groups decreased significantly before and after treatment, and the difference was statistically significant (P <0.05). Conclusion Red Toxia could correct the pelvic environment by regulating the balance of MMP-9 / TIMP-1 and effectively improve the clinical symptoms of patients with endometriosis.