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目的:探讨海口地区妇女人乳头瘤病毒(HPV)感染状况及其危险因素,为防治人乳头瘤病毒感染提供依据。方法:对海口地区3 230名妇女进行横断面调查,采用实时荧光PCR检测人乳头瘤病毒含量,并分析危险因素与人乳头瘤病毒感染的关系。结果:人乳头瘤病毒阳性表达率为30.34%(980/3 230);不同性生活持续年龄段的HPV感染罹患率无统计学差异(P>0.05);单因素分析显示,婚外性行为、吸烟、结婚次数>1、子宫颈糜烂/息肉、阴道滴虫及尿路感染等均是HPV感染的相关因素(OR值分别为1.691、1.571、1.410、1.230、1.260、1.571);多因素分析显示,人乳头瘤病毒感染与婚外性行为、尿路感染等显著相关(OR值分别为1.660、1.541)。结论:海口地区妇女HPV感染率较高,在性生活持续各年龄段均需预防HPV感染,而婚外性行为、尿路感染等是本地区妇女HPV感染的危险因素。
Objective: To investigate the status of human papillomavirus (HPV) infection and its risk factors in Haikou area and to provide basis for prevention and treatment of human papillomavirus infection. Methods: A total of 3 230 women in Haikou district were investigated by cross-sectional investigation. Real-time fluorescent PCR was used to detect the content of human papillomavirus. The relationship between risk factors and human papillomavirus infection was analyzed. Results: The positive rate of human papillomavirus was 30.34% (980/3 230). There was no significant difference in the prevalence of HPV infection among different sex life groups (P> 0.05). Univariate analysis showed that extra-marital sexual behavior, Smoking, the number of marriages> 1, cervical erosion / polyp, vaginal trichomoniasis and urinary tract infection were all related factors of HPV infection (OR values were 1.691,1.571,1.410,1.230,1.260,1.571 respectively); multivariate analysis showed , HPV infection was significantly associated with extramarital sex and urinary tract infection (OR 1.660 and 1.541 respectively). Conclusion: The HPV infection rate of women in Haikou area is high, and HPV infection should be prevented in all ages of sexual life, while the extramarital sex and urinary tract infection are the risk factors of HPV infection in this area.