目的:总结发病时间最长、病灶最大、反复生长的巨大尖锐湿疣的治疗情况,以探讨如何更好地治疗这类传播性疾病,从理论上和临床上重新认识该病的发生和归转。方法:反复27年复发尖锐湿疣患者1例,女性,有不洁性交史,曾以巨大生殖器疣入院手术治疗,疣体重4.5 Kg左右,另有散在发生于口唇,上颚,鼻腔,乳房等部位,双手指多发较大寻常疣,并留有影像和照片资料。首次治疗采用高频 OBJECTIVE: To summarize the treatment of giant condylomata acuminata, which has the longest onset time, the largest lesion size and the repeated growth, to explore how to treat such transmissible diseases better and re-recognize the occurrence and return of the disease theoretically and clinically. Methods: One case of recurrent condyloma acuminatum was found in 27 cases. The female had a history of unclean sexual intercourse and was admitted to hospital with huge genital warts. The weight of the wart was about 4.5 Kg, and another part occurred in the lips, upper jaw, nasal cavity and breast, Two fingers more common verruca vulgaris, and leave the image and photo information. The first treatment with high frequency