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目的:评价SSA、SSB和胞衬蛋白在诊断干燥综合征(SS)中的价值。方法:用酶联免疫吸附试验(ELISA)检测47例确诊为SS患者、20例其它自身免疫病(类风湿关节炎7例、SLE6例、自身免疫性肌炎7例)和20例体检健康者血清抗SSA、SSB和α-胞衬蛋白抗体,分析三种自身抗体阳性率。结果:抗SSA抗体、抗SSB抗体和抗α-胞衬蛋白抗体敏感性分别为76.6%、38.3%、42.6%;特异性分别为72.5%、95.0%、82.5%;三种抗体联合检测后敏感性为89.4%,特异性50.0%。结论:抗α-胞衬蛋白抗体与抗SSA、SSB抗体联合检测时可提高阳性率,对症状不典型的SS患者诊断有一定的补充意义。
PURPOSE: To evaluate the value of SSA, SSB and lumbrin in the diagnosis of Sjogren’s syndrome (SS). Methods: 47 patients diagnosed as SS, 20 other autoimmune diseases (rheumatoid arthritis in 7, SLE in 6, autoimmune myositis in 7) and 20 healthy controls were detected by enzyme linked immunosorbent assay (ELISA) Serum anti-SSA, SSB and α-litterin antibodies were analyzed for the positive rates of the three autoantibodies. Results: The sensitivities of anti-SSA antibody, anti-SSB antibody and anti-α-diterin antibody were 76.6%, 38.3% and 42.6% respectively; the specificity were 72.5%, 95.0% and 82.5% Sex was 89.4% and specificity was 50.0%. Conclusion: The detection rate of anti-α-litterin antibody in combination with anti-SSA and SSB antibodies can increase the positive rate, which is of some significance in the diagnosis of SS patients with atypical symptoms.