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本研究采用高效液相色谱法测定头孢呋辛血浓度。对单剂量及多剂量口服头孢呋辛酯后,该药在呼吸系统感染病人体内的药代动力学特性及血药浓度变化进行测定和讨论,并根据迭加原理预测多剂量给药后的药物浓度,将预测值与实测值进行比较,结果非常接近。将测定的时间药物浓度数据经3P87药物动力学程序处理,求出头孢呋辛酯在呼吸系统感染病人体内的药代动力学参数。其消除速率常数为0.38±0.04h~(-1);消除半衰期1.85±0.22h;达峰时间2.72±0.13h;峰浓度6.13±2.07mg/l;中央室分布容积23.89±4.79(l);血清总清除率14.66±3.34l/h;滞后时间1.88±0.07h。
In this study, the determination of cefuroxime blood concentration by high performance liquid chromatography. After oral administration of cefuroxime axetil in single and multiple doses, the pharmacokinetics and plasma concentration of the drug in patients with respiratory infection were measured and discussed, and the drug after multi-dose administration was predicted according to the superposition principle Concentration, the predicted value compared with the measured value, the result is very close. The measured time drug concentration data by 3P87 pharmacokinetic program processing, obtained cefuroxime axetil in patients with respiratory infection in vivo pharmacokinetic parameters. The elimination rate constant was 0.38 ± 0.04 h -1; the elimination half-life was 1.85 ± 0.22 h; the peak time was 2.72 ± 0.13 h; the peak concentration was 6.13 ± 2.07 mg / l; the distribution volume of the central chamber was 23.89 ± 4.79 (l); The total serum clearance rate of 14.66 ± 3.34l / h; lag time of 1.88 ± 0.07h.