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目的探讨宫颈高危人乳头瘤病毒(HPV)感染的危险因素。方法选取郑州大学第三附属医院2009年9月～2011年3月间行高危型HPV(HR-HPV)筛查的门诊或病房患者阳性病例306例,27例HPV-DNA阴性作为对照组,用杂交捕获二代法(HC2)检测HPV-DNA,所有患者均填写HPV感染相关危险因素调查表,单因素和多因素非条件Logistic回归分析的方法对调查信息进行分析。结果经单因素非条件Logistic回归分析,受教育程度,家庭人均收入,第一次结婚年龄、被动吸烟、曾经怀孕、人工流产、使用避孕套、第一次性生活年龄、性伴侣数与HPV感染存在相关性(P﹤0.05)。经多因素非条件Logistic回归分析,家庭人均收入,被动吸烟,使用避孕套,第一次性生活年龄有关(P﹤0.05)。结论被动吸烟、人工流产、性伴侣数多是HPV感染的危险因素(OR﹥1),受教育程度高、经济收入多、使用避孕套、第一次性生活年龄大是HPV感染的保护因素(OR﹤1)。因此应加强对HPV易感人群的卫生宣教与管理,从而预防宫颈癌的发生。
Objective To investigate the risk factors of cervical high risk human papillomavirus (HPV) infection. Methods A total of 306 cases of outpatient or ward patients with high-risk HPV (HR-HPV) screening from September 2009 to March 2011 were selected from the Third Affiliated Hospital of Zhengzhou University from September 2009 to March 2011. 27 cases were negative with HPV-DNA as the control group The second generation method (HC2) was used to detect HPV-DNA by hybridization. All patients were asked to fill in the questionnaire about risk factors of HPV infection, and univariate and multivariate non-conditional logistic regression analysis. Results According to the univariate non-conditional Logistic regression analysis, the level of education, the per capita income of the family, the first marriage age, the passive smoking, the previous pregnancy, the abortion, the use of condoms, the first sexual life, the number of sexual partners and HPV infection There was a correlation (P <0.05). By multivariate non-conditional logistic regression analysis, family per capita income, passive smoking, the use of condoms, the first sex life (P <0.05). Conclusions Passive smoking, induced abortion and number of sexual partners are mostly risk factors for HPV infection (OR> 1), with high level of education and economic income. The use of condoms and the first sexual life are the protective factors of HPV infection OR <1). Therefore, we should strengthen the health education and management of HPV-susceptible populations and thus prevent the occurrence of cervical cancer.