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目的:探讨2型糖尿病(T2DM)早期动脉粥样硬化(AS)发生的影响因素。方法:230例T2DM患者分为AS组(110例)和非AS组(120例),对两组多项临床指标及线粒体DNA(mtDNA)进行比较及相关分析。结果:AS组腰臀比(WHR)、收缩压(SBP)、舒张压(DBP)、吸烟指数(SI)、血尿酸(SUA)、C反应蛋白(CRP)、线粒体DNA16189T→C变异高于非AS组,差异有统计学意义。结论:T2DM患者合并早期大血管病变主要与腹型肥胖、吸烟、血压、SUA、CRP及遗传因素有关。
Objective: To investigate the influencing factors of early atherosclerosis (AS) in type 2 diabetes mellitus (T2DM). Methods: Two hundred and twenty T2DM patients were divided into AS group (n = 110) and non-AS group (n = 120). The clinical data and mtDNA of two groups were compared and analyzed. Results: The WHR, SBP, SI, SUA, CRP, and mitochondrial DNA 16189T → C in AS group were significantly higher than those in non - AS group, the difference was statistically significant. Conclusion: T2DM patients with early macrovascular complications are mainly associated with abdominal obesity, smoking, blood pressure, SUA, CRP and genetic factors.