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目的 研究并比较盐酸他可林（ＴＨＡ）在不同月龄大鼠体内的药物动力学。方法 青年大鼠和老龄大鼠分别ｉｖ和 ｉｇ ＴＨＡ ８ｍｇ／ｋｇ后，定时采血，用反相高效液相色谱法测定血药浓度，计算机拟合房室模型，并计算药动学参数。结果 两种大鼠静注或灌胃给药后，血药浓度－时间关系符合二室模型；老龄大鼠大多数时间声、的血药浓度显著高于青年大鼠；老龄大鼠静注的药动学参数Ｔ１／２α、Ｔ１／２β部和ＡＵＣ分别比青年大鼠大８０％、６３％和６２％；而灌胃时Ｔ１／２α、Ｔ１／２β、ＡＵＣ。Ｃｍ和Ｔｐ分别比青年大鼠大２９％。５６％、１００％、６８％和２１％，两种动物相比有显著性或非常显著性差异（Ｐ＜０．０５或 Ｐ＜ ０．０１）。结论 ＴＨＡ在老龄大鼠的吸收、分布，尤其是消除明显比青年大鼠慢。
Objective To study and compare the pharmacokinetics of tacrine hydrochloride (THA) in rats of different ages. Methods Young rats and old rats were iv and ig THA 8mg / kg, the timing of blood collection, determination of plasma concentrations of drugs by reversed-phase high performance liquid chromatography, computer-atrioventricular model, and calculated pharmacokinetic parameters. Results After two groups of rats were administered intravenously or gavage, the plasma concentration-time relationship was in accordance with the two-compartment model. The plasma concentration of the aged rats was significantly higher than that of the young rats in most of the time; The pharmacokinetic parameters T1 / 2α, T1 / 2β and AUC were 80%, 63% and 62% higher than those in young rats, respectively. Cm and Tp were 29% larger than young rats. 56%, 100%, 68% and 21%, respectively. There were significant or very significant differences between the two animals (P <0.05 or P <0.01). Conclusion The absorption, distribution and especially the elimination of THA in aged rats are obviously slower than those in young rats.