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目的 观察系统性红斑狼疮 (SLE)患者体内血小板活化状态。方法 采用酶联免疫吸附法 (ELISA)检测 32例SLE患者血浆 11 去氢 血栓烷B2 (DH TXB2 ) ,同时测定TXB2 ,并与对照组比较。结果 与对照组比较 ,SLE患者血浆DH TXB2 、TXB2 均显著增高 (P <0 0 1及P <0 0 5 ) ,且DH TXB2 增高程度明显高于TXB2 ,与对照组无重叠 ,肾受累者显著高于无肾脏受累者 (P <0 0 5 ) ,经治疗者显著低于初发未治疗者 (P <0 0 1) ,但仍高于对照组 (P <0 0 5 )。血浆TXB2 与DH TXB2 浓度与疾病活动指数均呈正相关 (r1=0 478,P <0 0 5及r2 =0 5 30 ,P <0 0 1)。结论 血浆DH TXB2 水平测定是准确反映血小板活化的指标 ,SLE患者体内血小板高度活化
Objective To observe the platelet activation in patients with systemic lupus erythematosus (SLE). Methods The plasma levels of TXB2 and TXB2 in 32 SLE patients were determined by enzyme-linked immunosorbent assay (ELISA), and compared with the control group. Results Compared with the control group, the levels of plasma TXB2 and TXB2 in patients with SLE were significantly increased (P <0.01 and P <0.05), and the increased levels of DH TXB2 were significantly higher than those in the control group (P <0 05). The treated group was significantly lower than those of the first untreated group (P <0.01), but still higher than the control group (P 0 05). Plasma TXB2 and DH TXB2 concentrations were positively correlated with disease activity index (r1 = 0 478, P <0 05 and r2 = 0 5 30, P 0 01). Conclusion The determination of plasma DH TXB2 level is an accurate indicator of platelet activation. Platelets are highly activated in SLE patients