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目的探讨薄芝糖肽局部封闭联合他克莫司乳膏治疗局限性硬皮病(LS)的病理变化。方法采用苏木素-伊红染色方法,观察32例LS患者治疗前后表皮、胶原、附属器、血管及炎症细胞的病理变化。结果32例LS患者皮损治疗后毛囊等附属器数量增加,浅层毛细血管增多、炎细胞浸润范围、胶原累及范围及胶原细胞核变化和治疗前相比差异无统计学意义(P>0.05)。治疗后胶原密度由致密、均质化明显转为稍致密有空隙状态,炎性细胞浸润密度明显改善(P均<0.05)。结论薄芝糖肽局封联合他克莫司乳膏对早期LS炎症控制有一定效果,可有效抑制成纤维细胞增殖。
Objective To investigate the pathological changes of limited scleroderma (LS) treated with topical glycosaminoglycan combined with tacrolimus cream. Methods The hematoxylin-eosin staining method was used to observe the pathological changes of epidermis, collagen, appendages, blood vessels and inflammatory cells in 32 patients with LS before and after treatment. Results There was no significant difference in the number of hair follicles and other appendages, superficial capillaries, infiltration of inflammatory cells, extent of collagen invasion and nuclear changes of collagen in 32 patients with LS after skin lesion treatment (P> 0.05). After treatment, the density of collagen was changed from dense and homogenized to slightly dense and interstitial state, and the infiltration density of inflammatory cells was significantly improved (all P <0.05). Conclusions The combination of bocarb glycoside peptide and tacrolimus cream has certain effect on early LS inflammation control and can effectively inhibit the proliferation of fibroblasts.