异喹啉类化合物有较强的抗高血压、抗心律失常、抗血栓活性。以往对苄基异喹啉的结构改造主要集中于１位和２位，１位取代基为取代的苄基或萘甲基，结构变化不大，而针对２位进行分子设计，合成了许多化合物。研究结果表明，异喹啉母环与１位次甲基连接的芳环在空间构象上... Isoquinolines have strong anti-hypertensive, anti-arrhythmic, anti-thrombotic activity. In the past, the structural modifications of benzyl isoquinoline mainly focused on the 1st and 2nd positions. The 1st substituent was a substituted benzyl or naphthylmethyl group, and its structure did not change much. However, for the 2-position molecular design, many compounds were synthesized . The results show that the isoquinoline mother ring and a methine group connected to the aromatic ring in the spatial conformation ...