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目的:测定重度子痫前期(SPE)患者在妊娠24～28周时的血清脂联素(APN)水平变化,并研究其与此妊娠时期的体重指数(body mass index,BMI)、体脂百分数(BF%)及血脂水平的相关性。方法:随机选择来青岛市中心医院进行产前检查并于孕晚期发展为SPE而无其他妊娠并发症或合并症的单胎妊娠妇女30例为实验组,同一时期进行产前检查至孕晚期仍为正常的单胎妊娠妇女30例为对照组。实验组和对照组妊娠妇女在妊娠24～28周时采用放射免疫法测定其血清脂联素和血脂水平,同时测算BMI、BF%等,并进行相关分析。结果:实验组血清脂联素水平低于对照组,两组比较差异有统计学意义(P<0.01);实验组血清脂联素水平与妊娠24～28周的BMI及BF%呈负相关(γ=-0.96,P<0.01;γ=-0.92,P<0.01),与甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)呈负相关(γ=-0.94,P<0.01;γ=-0.86,P<0.01),与体重增加百分率、总胆固醇(TC)无相关性,与低密度脂蛋白胆固醇(LDL-C)呈正相关(γ=0.98,P<0.01)。结论:低脂联素水平可能成为中期妊娠SPE患者早期诊断及预测的重要指标。
OBJECTIVE: To determine the changes of serum adiponectin (APN) levels in patients with severe preeclampsia (SPE) between 24 and 28 weeks of gestation, and to investigate the association between the levels of body mass index (BMI) and body fat percentage (BF%) and blood lipid levels. Methods: Totally 30 singleton pregnant women randomly selected from Qingdao Central Hospital for prenatal examination and developed into SPE during the third trimester of pregnancy without other complications or complications of pregnancy were selected as the experimental group. During the same period, prenatal examination was performed until the third trimester of pregnancy 30 cases of normal singleton pregnancy women as the control group. The pregnant women in the experimental group and the control group were measured serum levels of adiponectin and blood lipid by radioimmunoassay 24 to 28 weeks gestation, and the BMI, BF%, etc. were calculated and analyzed at the same time. Results: Serum levels of adiponectin in the experimental group were lower than those in the control group (P <0.01). Serum levels of adiponectin in the experimental group were negatively correlated with BMI and BF% in the 24-28 weeks of gestation γ = -0.96, P <0.01; γ = -0.92, P <0.01), negatively correlated with triglyceride (TG) and high density lipoprotein cholesterol (HDL- γ = -0.86, P <0.01). There was no correlation with weight gain, total cholesterol (TC) and LDL-C (γ = 0.98, P <0.01). Conclusion: Low adiponectin levels may be an important indicator of early diagnosis and prediction of SPE in the second trimester of pregnancy.