对更年期妇女来说,体内雌激素水平降低是导致各种不适(更年期综合征)的一个重要原因,所以给予适量的雌激素对减轻更年期综合征具有一定的治疗作用。但是自从全世界广泛使用雌激素替代疗法以来,欧美国家发现乳腺癌、脑中风、静脉血栓和心脏病的发病率有呈升高的趋势,这说明在这些患者体内,雌激素的代谢过程已发生异常。目前,在美国和西欧国家已停止使用雌 For menopausal women, the reduction of estrogen levels in the body is an important cause of various discomforts (climacteric syndromes), so administering an appropriate amount of estrogen has a therapeutic effect in reducing menopausal syndrome. However, since the widespread use of estrogen replacement therapy worldwide, the incidence of breast cancer, stroke, venous thrombosis and heart disease in Europe and the United States has shown an upward trend, suggesting that estrogen metabolism has taken place in these patients abnormal. At present, the United States and Western European countries have stopped using the female