【摘 要】
：
Aberrant expression ofcarcinoembryonic antigen(CEA)is a common feature for multiple types of cancer,which makes it an attractive target for anticancer therapy.C
【机 构】
：
Laboratory Animal Center,Department of Gastroenterology,Institute of Radiation Medicine,Department o
论文部分内容阅读
Aberrant expression ofcarcinoembryonic antigen(CEA)is a common feature for multiple types of cancer,which makes it an attractive target for anticancer therapy.CAtin is a novel dual cancer-specific fusion protein,composed of an anti-CEA single-chain disulfide-stabilized Fv antibody(scdsFv)and Apoptin,a tumor-specific apoptosis-inducing protein.Oral squamous cell carcinoma(OSCC)is an important healthcare problem in the clinic.To evaluate the anticancer effects of CAtin on OSCC,7,12-dimethylbenz[a]anthracene(DMBA)was used to induce oral carcinogenesis and premalignant lesions in the buccal pouch of Chinese hamster,and the antitumor effects of CAtin were determined in pre-cancer,cancer and post-operatative cancer models,respectively.The results show that the administration of CAtin delayed the malignant transformation of early stage cancerous lesions,inhibited the growth of established solid oral tumors and reduced the post-operatative relapse of lesions,with no significant systemic toxicity.This study demonstrates that CAtin may have potential for the treatment of OSCC,and the development of preventive strategies based on CAtin may offer a practical approach for the treatment of human oral tumors.
其他文献
The shape and size of particles are understood to affect the bulk behaviour of powders,though there are but few studies that present quantitative information on
In this article,the unique continuation and persistence properties of solutions of the 2-component Degasperis-Procesi equations are discussed.It is shown that s
This paper studies the dynamic buckling behavior of multi-walled carbon nanotubes (MWNTs) subjected to step axial loading.A buckling condition is derived,and nu
In this article,we study isoperimetric problems of the calculus of variations with left and right Riemann-Liouville fractional derivatives. Both situations when
The daily sunspot numbers of the whole disk as well as the northern and southern hemispheres from 1945 January 1 to 2010 December 31 are used to investigate the
The synthesis of a new type of X-ray-sensitive compound “di-(1-hydroxylundecyl)diselenide” and its application in the preparation of a new type of liposome wi
A novel disulphide derivatised deuteroporphyrin 2,7,12,18-tetramethyl-13,17-(propionylaminoethyldithioethyl amino-formylethyl)-29,34-bis-(methoxyformyl)porphyri
The aim of this article is to study some invariants of associative algebras under stable equivalences of Morita type.First of all,we show that,if two finite-dim
The potential effects of nanoscale CuO(nCuO),nanoscale ZnO(nZnO)and their mixtures on Daphnia magna were investigated,including 48-h acute toxicity and 21-d chr