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目的探讨11C-胆碱(11C-CHO)PET/CT在脑胶质瘤手术、放疗或化疗后残存肿瘤或复发诊断中的应用价值。方法 22例脑胶质瘤患者,均行手术切除,术后行放疗和化疗。治疗结束后对所有脑内残存病灶行11C-CHOPET/CT显像和MR I检查,并再次切除瘤灶或活检进行病理检查或进行长期随访。肿瘤残存病灶以CT所示病灶部位11C-CHO异常浓聚,超过周围正常脑组织为阳性。其摄取量以最大标准摄取值SUVmax表示。结果 22例脑胶质瘤患者经手术及随访证实共有16例残存或复发,6例未复发。11C-CHO显像真阳性16例,真阴性5例,假阳性1例,假阴性0例。11C-CHO PET/CT显像诊断脑胶质瘤复发的敏感度100%(16/16),特异度83.3%(5/6),准确性95.5%(21/22)。ROC分析显示11C-CHO PET/CT显像诊断脑胶质瘤复发曲线下面积为曲线下面积(AUC)为0.917(95%C I为0.840~0.994)。结论 11C-CHO PET/CT对脑胶质瘤残存或复发有较好的诊断价值。
Objective To investigate the diagnostic value of 11C-CHO PET / CT in the diagnosis of residual tumor or recurrence after glioma surgery, radiotherapy or chemotherapy. Methods Twenty - two patients with glioma underwent surgical resection and received radiotherapy and chemotherapy. After treatment, all the remaining lesions in the brain were examined by 11C-CHOPET / CT imaging and MRI, and resection of tumor or biopsy for pathological examination or long-term follow-up. The residual tumor of the tumor was abnormally concentrated at 11C-CHO of lesion site as shown by CT, which was more than normal brain tissue around. Its intake to the maximum standard intake value SUVmax said. Results Twenty-two cases of glioma patients were confirmed by operation and follow-up. There were 16 cases with residual or recurrent disease and 6 cases without recurrence. 11C-CHO imaging true positive 16 cases, 5 cases of true negative, false positive in 1 case, false negative in 0 cases. The sensitivity and specificity of 11C-CHO PET / CT in diagnosis of recurrent glioma were 100% (16/16), 83.3% (5/6), and 95.5% (21/22) respectively. ROC analysis showed that the area under the curve (AUC) for 11C-CHO PET / CT imaging in diagnosing gliomas was 0.917 (95% CI 0.840 to 0.994). Conclusion 11C-CHO PET / CT has good diagnostic value for the residual or recurrent glioma.