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几年来我国在克山病、大骨节病的研究中,发现病儿心肌、红细胞膜的形态、结构和功能方面存在异常,在以模拟克山病区居民生活特点、控制磷脂和硒的动物模型实验中,出现了类似克山病心肌损伤的一系列病变(如心电图、病理形态、代谢及心肌磷脂组成的改变),表明控制磷脂代谢可以改变某些组织细胞膜的结构和功能,这对研究心血管病等老年性疾病的发生及其防治将有重要意义,即修饰改善活体的细胞膜将是可能的。本文是我们通过一种控制磷脂代谢的基础饲料喂养动物,观察其对心肌细胞膜组分、膜结合酶活性乃至心肌功能的影响的实验结果,同时对补充磷脂的效应进行了平行观察。
In the past few years, Keshan disease and Kashin-Beck disease were found in our country. The morphological, structural and functional abnormalities of myocardium and erythrocyte membrane were found abnormal in our country. In the animal model which controlled the living characteristics of Keshan ward and controlled the phospholipids and selenium, In the experiment, a series of lesions (such as electrocardiogram, pathomorphology, metabolism and myocardial phospholipid changes) were found in the myocardium of Keshan disease, indicating that the control of phospholipid metabolism could change the structure and function of some cell membranes. Vascular diseases and other diseases of the elderly and its prevention and treatment will be of great significance, that is modified to improve the living cell membrane will be possible. This article is the result of our experiments on the effects of feeding phospholipids on the membrane components, membrane-bound enzyme activities and even myocardial function of animals by controlling the metabolism of phospholipids and observing the effect of phospholipid supplementation in parallel.