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用淋巴细胞分化抗原的系列单抗隆抗体,动态观察流行性出血热(EHF)外周血淋巴细胞亚群的变化。发现CD_8~+细胞数在2—5及9—12病日明显增加,CD_4~+/CD_8~+比值倒置或下降,16—19病日逐渐恢复正常。B~+、IL-2R~+和HLA-DR~+细胞数在病程的不同阶段均显著增高。在疾病的早期重、中型患者B~+、IL-2R~+及HLA-DR~+细胞数高于轻型患者。特异性免疫球蛋白治疗后B~+、IL-2R~+和HLA-DR~+细胞数与对照组相比明显降低。提示:EHF患者细胞免疫功能增强,细胞免疫可能参与本病的发病机制。特异性免疫球蛋白的应用似有改善细胞免疫功能紊乱的作用。
A series of monoclonal antibodies against lymphocyte differentiation antigen were used to observe the changes of peripheral blood lymphocyte subsets in epidemic hemorrhagic fever (EHF). It was found that the number of CD_8 ~ + cells was significantly increased at 2-5 and 9-12 days, the ratio of CD_4 ~ + / CD_8 ~ + was upside down or down, and gradually returned to normal on the 16th and 19th day. The number of B ~ +, IL-2R ~ + and HLA-DR ~ + cells were significantly increased at different stages of the course of disease. In the early stage of disease, the number of B ~ +, IL-2R ~ + and HLA-DR ~ + cells were higher in patients with moderate and severe type than in those with mild type. The number of B ~ +, IL-2R ~ + and HLA-DR ~ + cells after treatment with specific immunoglobulin was significantly lower than that of the control group. Tip: EHF patients with enhanced cellular immunity, cellular immunity may be involved in the pathogenesis of the disease. The use of specific immunoglobulins appears to improve the cellular immune dysfunction.