肾小球基膜是血浆蛋白的机械和电荷屏障。生理状况下,仅低分子量的血浆蛋白能从基膜滤出。肾小球基膜损伤后,中、高分子量的血浆蛋白滤出增加,导致近端肾小管过度重吸收和转运蛋白。近年来对伴蛋白尿的慢性肾脏疾病进行性恶化的病理机制进行了广泛研究。肾小管上皮细胞受体与蛋 The glomerular basement membrane is a mechanical and charge barrier of plasma proteins. Physiologically, only low molecular weight plasma proteins can be filtered out of the basement membrane. Glomerular basement membrane injury, medium and high molecular weight of plasma protein increased filtration, leading to proximal tubular reabsorption and transporter protein. In recent years, extensive studies have been conducted on the pathological mechanism of progressive deterioration of chronic kidney disease associated with proteinuria. Tubular epithelial cells receptors and eggs