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血红素加氧酶 (ｈｅｍｅｏｘｙｇｅｎａｓｅＨＯ)由Ｔｅｎｈｕｎｅｎ等于 196 8年首次发现存在于微粒体中 ,是催化血红素 (铁原卜啉 )形成胆绿素和ＣＯ的限速酶。在哺乳动物体内 ,血红素代谢为胆绿素的途径中同时需要有ＮＡＤＰＨ ,ＮＡＤＰＨ 细胞色素Ｐ 4 5 0还原酶和分子氧
Hemeoxygenase HO was first discovered in microsomes by Tenhunen et al. In 1988. It is a rate-limiting enzyme that catalyzes the formation of bilirubin and CO from heme. In mammals, the pathway of heme metabolism to biliverdin requires both NADPH, NADPH cytochrome P450 reductase and molecular oxygen