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细胞因子诱导的杀伤细胞(cytokine-induced killer,CIK)是一种由多种细胞因子诱导的以表达CD3+和CD56+细胞为主的异质性细胞群,对多种肿瘤细胞均有明显的细胞毒活性。临床常用的CIK主要来源于人脐血和外周血,其杀瘤机制不同,前者以诱导肿瘤细胞的坏死为主,后者通过诱导肿瘤细胞的凋亡而发挥作用。它们均通过表达CD56分子促进细胞间的黏附和结合,能释放穿孔素、细胞溶解素等使靶细胞产生渗透性溶解。当效靶细胞比为30∶1时,抑瘤效果较好。
Cytokine-induced killer (CIK) is a heterogeneous cell population that is mainly induced by various cytokines to express CD3 + and CD56 + cells. It has obvious cytotoxicity on many kinds of tumor cells active. Clinically common CIK mainly comes from human umbilical cord blood and peripheral blood, and its killing mechanism is different. The former mainly induces necrosis of tumor cells, and the latter plays a role in inducing tumor cell apoptosis. Both of them express CD56 molecules to promote cell adhesion and binding, and release perforin and cytolysin to make target cells permeate and dissolve. When the effective target cell ratio is 30: 1, the antitumor effect is better.