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观察肺心病急性加重期和肺癌患者血浆内皮素（ＥＴ）及心钠素（ＡＮＰ）各３０例。结果表明：肺心病急性加重组（下简称肺心加重组）血浆ＥＴ及ＡＮＰ水平均较正常对照组显著升高（Ｐ＜０．０１及Ｐ＜０．０５），且ＥＴ水平与ＡＮＰ及ＰａＣＯ２呈正相关（ｒ＝０．７８，Ｐ＜０．０１；ｒ＝０．６６Ｐ＜０．０１），而与Ｐ３Ｏ；及ｐＮ呈负相关（ｒ＝－０．９５Ｐ＜０．０１；ｒ＝－０．５３Ｐ＜０．０５）；肺癌组ＥＴ，ＡＮＰ亦较对照组显著升高（Ｐ＜０．０５），且ＥＴ与ＡＮＰ呈正相关（ｒ＝０．７９Ｐ＜０．０１）。此结果提示在肺动脉高压、肺心病的形成和发展、肺癌的发生发展以及ＡＮＰ分泌调控中，内皮素可能起着重要作用。缺氧和高碳醚血症可能是ＥＴ合成、分泌的刺激因子。
To observe the acute exacerbation of pulmonary heart disease and lung cancer patients with plasma endothelin (ET) and atrial natriuretic peptide (ANP) in 30 cases. The results showed that the levels of plasma ET and ANP in acute pulmonary heart disease group were significantly higher than those in normal control group (P <0.01 and P <0.05), and the levels of ET were positively correlated with ANP and PaCO2 (R = 0.78, P <0.01; r = 0.66 P <0.01), but negatively correlated with P3O and pN (r = -0.95 P <0.01; r = 0.53P <0.05). The levels of ET and ANP in lung cancer group were significantly higher than those in control group (P <0.05), and ET was positively correlated with ANP (r = 0.79P <0.01). This result suggests that endothelin may play an important role in the formation and development of pulmonary hypertension, pulmonary heart disease, the development of lung cancer and the regulation of ANP secretion. Hypoxia and hypercapneaia may be ET synthesis and secretion of stimuli.