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目的探讨胃肠道多原发恶性肿瘤的临床病理特点。方法通过计算机病案管理系统检索我院近５年手术治疗的胃肠道恶性肿瘤８２０例，其中３５例经病理确诊为胃肠道多原发癌，发生率为４．３％。男女之比为２．５∶１。结果多原发大肠癌２５例，胃及胃肠多原发癌１０例；同时癌２３例，异时癌１２例；胃多原发癌的发病年龄、病程、组织分化不良程度均高于大肠多原发癌及胃肠多原发癌。胃肠道多原发癌发病年龄轻，癌灶分布以右半结肠较多，大肠多原发癌的腺瘤伴发率较高，这些对癌症普查及手术治疗都有指导作用。同时癌经手术治疗预后与单发癌相似，而异时癌预后好于单发癌。结论上述研究对阐明多原发癌的发生机制、提高病人５年生存率有重要意义。
Objective To investigate the clinicopathological features of multiple primary malignancies of the gastrointestinal tract. Methods A total of 820 cases of gastrointestinal malignancies treated surgically in our hospital during the last 5 years were retrieved by a computerized medical record management system. Among them, 35 cases were diagnosed as having multiple primary gastrointestinal cancers by pathology. The incidence rate was 4.3%. The male to female ratio is 2.5:1. Results There were 25 cases of primary colorectal cancer, 10 cases of multiple primary gastric and gastrointestinal cancers, 23 cases of concurrent cancers, and 12 cases of different time cancers. The age, course of disease and poor tissue differentiation of primary gastric cancer were higher than those of the large intestine. Multiple primary cancers and multiple primary gastrointestinal cancers. The incidence of multiple primary cancers of the gastrointestinal tract was younger, the distribution of tumors was more in the right colon, and the incidence rate of adenomas with multiple primary colon cancers was higher. These have a guiding role in cancer screening and surgical treatment. At the same time, the prognosis of cancer surgery is similar to that of single cancer, and the prognosis of different time cancer is better than that of single cancer. Conclusion The above studies are important for elucidating the mechanism of multiple primary cancers and improving the 5-year survival rate of patients.