论文部分内容阅读
目的:研究慢性阻塞性肺疾病(COPD)大鼠肺组织中信号转导转录激活因子4(STAT4)和6(STAT6)蛋白表达的变化,探讨其在COPD发病中的作用。方法:首先复制COPD大鼠模型,然后采用免疫组织化学法检测COPD组及对照组大鼠肺组织STAT4和STAT6蛋白的表达。结果:STAT4蛋白在COPD大鼠肺组织中呈不同强度的阳性表达。而STAT6蛋白在COPD大鼠肺组织中的表达则低于对照组(P<0.01)。经统计学分析,两因子呈负相关性(r=-0.783,p<0.01)。结论:COPD大鼠肺组织中STAT4蛋白的表达占优势,而STAT6蛋白的表达被抑制。
Objective: To study the changes of the expression of signal transducer and activator of transcription 4 (STAT4) and 6 (STAT6) protein in lung tissue of chronic obstructive pulmonary disease (COPD) rats and to explore its role in the pathogenesis of COPD. Methods: First COPD rat model was duplicated, then the expression of STAT4 and STAT6 protein in lung tissue of COPD group and control group were detected by immunohistochemistry. Results: The expression of STAT4 protein in the lung tissue of COPD rats showed different intensity. The expression of STAT6 protein in COPD rats lung tissue was lower than the control group (P <0.01). Statistically, the two factors were negatively correlated (r = -0.783, p <0.01). Conclusion: STAT4 protein expression is predominant in lung tissue of COPD rats, but STAT6 protein expression is inhibited.