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目的 探讨乳化 -分散法合成与制备血管内皮生长因子 (VEGF)缓释微粒的效果。方法 采用乳化 -分散法 ,将可生物降解高分子聚乳酸 /乙醇酸共聚物 (PLGA)对VEGF进行包裹 ,合成可缓慢释放的微粒。用激光粒度分析仪测量微粒的平均粒径。结果 用乳化 -分散法 ,经 5次实验共制得 1 0 0份含VEGF的缓释微粒。测量其平均粒径为 0 2～ 0 3 3 μm。 结论 乳化 -分散法是合成与制备血管内皮生长因子缓释微粒的较好方法之一。
Objective To investigate the effect of emulsion-dispersion on the synthesis and preparation of vascular endothelial growth factor (VEGF) sustained-release particles. Methods The biodegradable polymer PLA / PLGA was used to encapsulate VEGF by emulsion-dispersion method to synthesize slowly-released microparticles. The average particle size of the particles was measured with a laser particle size analyzer. Results With emulsion-dispersion method, a total of 100 particles of VEGF-containing sustained-release microparticles were obtained after 5 experiments. The average particle size was measured from 0 2 to 0 3 3 μm. Conclusion Emulsification-dispersion method is one of the better ways to synthesize and prepare vascular endothelial growth factor sustained-release particles.