正常妊娠期间,胎盘相对缺氧,易受到氧化应激的影响。先兆子痫患者中,母体血管不良重构加剧胎盘的氧化应激反应,该现象被认为是妊娠高血压的重要病因之一。新证据表明,血红素氧化酶(heme oxygenase,HO)1是正常妊娠胎盘和心血管功能的重要调控因子。该文研究抑制HO对大鼠妊娠后期血压、血管 During normal pregnancy, the placenta is relatively hypoxia, susceptible to oxidative stress. In preeclampsia, maternal vascular malformation remodeling aggravates placental oxidative stress, a phenomenon considered to be one of the major causes of pregnancy-induced hypertension. New evidence suggests that heme oxygenase (HO) 1 is an important regulator of placenta and cardiovascular function in normal pregnancy. This article studies the inhibition of HO on blood pressure and blood vessels in late pregnancy