胰岛因子1(Islet1,ISL1),又称胰岛素增强子结合蛋白1,以多效转录因子的身份在多种组织器官的发育及成熟中发挥作用.ISL1在心、胰腺、神经系统等组织器官的胚胎发育过程中发挥重要作用.Isl1基因敲除可导致小鼠心发育不全,4种胰岛内分泌细胞缺失,以及运动神经元分化、迁移障碍等.ISL1具有促进增殖、抑制凋亡的重要功能.近年的研究表明,ISL1在多种肿瘤发生中存在异常高表达.然而,其在肿瘤发生中的具体作用与机制尚未被阐明,有待进一步探索. Islet1 (ISL1), also known as Insulin-like enhancer-binding protein 1, plays a role in the development and maturation of multiple tissues and organs as a pleiotropic transcription factor.ISL1 is expressed in embryos of tissues and organs such as heart, pancreas and nervous system Plays an important role in the development of the process.Isl1 knockout can lead to cardiac hypoplasia in mice, four kinds of islet endocrine cells missing, as well as motor neuron differentiation, migration disorders, etc. ISL1 has an important role in promoting proliferation and inhibiting apoptosis in recent years Studies have shown that ISL1 is highly expressed in a variety of tumorigenesis, however, the specific role and mechanism of ISL1 in tumorigenesis has not been elucidated yet, and remains to be further explored.