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作者用含1%人体白蛋白的鸡胚成纤维细胞麻疹疫苗气雾免疫109名不同月龄的健康儿童,观察儿童的免疫应答。吸入时间为30秒。免疫后随访21天,免疫前、免疫后8周和8个月测定血凝抑制(HAI)和蚀斑中和(PN)抗体滴度。结果表明,免疫前有些婴儿无母体HAI抗体,但有PN抗体(滴度为25～140)。免疫前后都能测到PN和HAI抗体的3～24月龄婴儿有23名,其中免疫前PN抗体滴度≥50的5名3～3月龄婴儿,气雾免疫后8周和8个月均
The authors immunized 109 healthy children of different ages with an aerosol of chicken embryo fibroblast measles vaccine containing 1% human albumin to observe the immune response in children. Inhalation time is 30 seconds. Hematoxylin-eosin (HAI) and plaque-neutralizing (PN) antibody titers were measured 21 days after immunization, before immunization, at 8 weeks and 8 months after immunization. The results showed that some infants did not have maternal HAI antibodies before immunization, but had PN antibodies (titer 25-140). Twenty-three to 24-month-old infants were tested for PN and HAI antibodies before and after immunization, including 5 infants aged 3 to 3 months with pre-immunization PN antibody titers of ≥50, eight weeks and eight months after aerosol immunization all