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目的：研究细胞周期蛋白依赖性激酶抑制因子（ｃｙｃｌｉｎｄｅｐｅｎｄｅｎｔｋｉｎａｓｅｉｎｈｉｂｉｔｏｒ，ＣＤＫＩ）ｐ２１ＷＡＦ１／ＣＩＰ１在膀胱移行细胞癌中表达情况，并探讨ｐ２１ＷＡＦ１／ＣＩＰ１表达与膀胱移行细胞癌临床病理指标的相关性。方法：应用Ｓ－Ｐ免疫组织化学方法检测９１例膀胱移行细胞癌（其中包括ＴａＧ１期膀胱移行细胞癌１５例）ｐ２１ＷＡＦ１／ＣＩＰ１蛋白表达情况，并探讨ｐ２１ＷＡＦ１／ＣＩＰ１表达与膀胱移行细胞癌的分化程度、浸润深度、淋巴结转移、ＴＮＭ分期等的相关性。结果：膀胱移行细胞癌ｐ２１ＷＡＦ１／ＣＩＰ１阳性表达率为４８．４％（４４／９１）；其中高、中分化的膀胱移行细胞癌ｐ２１ＷＡＦ１／ＣＩＰ１阳性表达率为５８．５％（３８／６５），低分化为２３．１％（６／２６），组间差异显著（Ｐ＜０．０５）；ｐ２１ＷＡＦ１／ＣＩＰ１阳性表达率ＴａＧ１期膀胱移行细胞癌为９３．３％（１４／１５），Ｔ１＋Ｔ２期为５２．１％（２５／４８），Ｔ３＋Ｔ４期为１７．９％（５／２８），３组间差异显著（Ｐ＜０．０５）；ＴＮＭ分期Ⅰ～Ⅱ期膀胱移行细胞癌ｐ２１ＷＡＦ１／ＣＩＰ１阳性表达率为５７．４％（３５／６１），Ⅲ～Ⅳ期为３０．
Objective: To investigate the expression of cyclin-dependent kinase inhibitor (CDKI) p21WAF1 / CIP1 in bladder transitional cell carcinoma and to investigate the correlation between the expression of p21WAF1 / CIP1 and the clinicopathological parameters of bladder transitional cell carcinoma. Methods: The expression of p21WAF1 / CIP1 protein in 91 cases of transitional cell carcinoma of the bladder (including 15 cases of transitional cell carcinoma of the bladder in TaG1 stage) was detected by S-P immunohistochemistry. The expression of p21WAF1 / CIP1 in bladder transitional cell carcinoma , Depth of invasion, lymph node metastasis, TNM staging and so on. Results: The positive rate of p21WAF1 / CIP1 expression in bladder transitional cell carcinoma was 48.4% (44/91), and the positive rate of p21WAF1 / CIP1 in high and moderately differentiated bladder transitional cell carcinoma was 58.5% (38/65) (P <0.05). The positive rate of p21WAF1 / CIP1 in transitional cell carcinoma of the bladder was 93.3% (14/15) in the stage of TaG1, T1 + T2 stage (P <0.05). The positive rate of p21WAF1 / CIP1 in transitional cell carcinoma of the bladder (TNM stage Ⅰ ~ Ⅱ) was 52.1% (25/48) The positive rate was 57.4% (35/61) and the stage Ⅲ ~ Ⅳ was 30.