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目的 :探讨胰岛素抵抗、甲状腺及性腺激素水平下降与 2型糖尿病胆石症的关系。方法 :采用病例对照研究的方法 ,比较 36例老年 2型糖尿病 (T2 DM)伴胆石症和 36例 T2 DM不伴胆石症患者的胰岛素敏感指数 (ISI)、甲状腺激素 (TH)、雌二醇 (E2 )、E2 /睾酮 (T)和血脂的变化。结果 :T2 DM伴胆石症组空腹胰岛素 (Flns)、甘油三脂 (TG)明显升高 ,ISI、HDL- C、TT3、FT3显著性降低 (P <0 .0 5 )。多元回归分析显示 ,T2 DM胆石症与 TG呈显著正相关、与 ISI、TT3、FT3呈显著负相关 ;与 E2 、E2 / T无关。结论 :胰岛素抵抗、甲状腺激素水平低下、高脂血症是 T2 DM胆石症形成的危险因素。
Objective: To investigate the relationship between insulin resistance, thyroid gonadotropin levels and type 2 diabetic cholelithiasis. Methods: A case-control study was conducted to compare the insulin sensitivity index (ISI), thyroid hormones (TH), estradiol and triglyceride levels in 36 elderly patients with type 2 diabetes mellitus (T2DM) with cholelithiasis and 36 patients with T2DM without cholelithiasis (E2), E2 / testosterone (T) and blood lipid changes. Results: Fasting insulin (Flns), triglyceride (TG), and ISI, HDL-C, TT3 and FT3 in T2DM with cholelithiasis were significantly decreased (P <0.05). Multivariate regression analysis showed that T2DM cholelithiasis was positively correlated with TG and negatively correlated with ISI, TT3 and FT3, but not with E2 and E2 / T. Conclusion: Insulin resistance, low thyroid hormone levels, and hyperlipidemia are risk factors for the development of T2DM cholelithiasis.