本文报告酪·精二肽的镇痛作用,对纹状体多巴胺代谢的影响,对皮层和海马乙酰胆碱变化率的影响以及阿片受体结合试验。以小鼠甩尾行为为指标,脑池内注射酪·精二肽100微克和200微克后,小鼠甩尾的潜伏期增加,此种作用强于甲硫氨酸脑啡肽而弱于 D-丙氨酸~2-D-亮氨酸~5-亮氨酸脑啡肽(DADLE,一种亮氨酸脑啡肽的抗酶解衍生物),且能被预先腹腔注射 This article reports the analgesic effect of zygophospeptide on the dopaminergic metabolism of the striatum, the effect on the rate of change of acetylcholine in the cortex and hippocampus, and the opioid receptor binding assay. Mouse tail flick behavior as an indicator, intracisternal injection of 100 mg and 200 g cheese · refined dipeptide mouse tail flick latency increased, this effect is stronger than methionine enkephalin and weaker than D-C Leucine ~ 2-D-leucine ~ 5-leucine enkephalin (DADLE, an anti-enzymatic derivative of leucine enkephalin) and can be preperitoneally injected