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目的:观察胃粘膜保护剂替普瑞酮、麦滋林对胃粘膜幽门螺杆菌(Hp)感染和粘膜防御能力的作用。方法:用比色的方法测胃粘膜氨基已糖含量,用W-S银染色法检查Hp,观察1993年~1994年中收治的慢性浅表性胃炎患者。结果:替普瑞酮增加Hp阴性(18±5)mg/g和阳性(16±4)mg/g病人的胃粘膜氨基已糖含量;安滋林组治疗前后氨基已糖无明显增加。替普瑞酮、麦滋林抑制Hp,有效抑制率分别为76.92%和77.78%,两者无显著差异(P<0.05)。结论:替普瑞酮和安滋林抑制Hp的生长,这种抑制作用似乎和氨基已糖的增加关系不十分密切。
Objective: To observe the effect of gastric mucosal protective agent teprenone and mazlin on gastric mucosal Helicobacter pylori (Hp) infection and mucosal defense. Methods: Gastric mucosal aminohexose content was measured by colorimetric method. Hp was detected by W-S silver staining. The patients with chronic superficial gastritis admitted from 1993 to 1994 were observed. Results: Teprenone increased the content of aminohexose in gastric mucosa in Hp negative (18 ± 5) mg / g and positive (16 ± 4) mg / g patients, while the Aminzamide group had no significant increase before and after treatment. Teprenone, MaiZhiLin inhibit Hp, the effective inhibition rates were 76.92% and 77.78%, no significant difference between the two (P <0.05). CONCLUSIONS: Teprenone and Arzolin inhibit the growth of Hp, and this inhibitory effect appears to be less closely related to the increase in hexose aminoglycoside.