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长期以来,人们一直以为甲型肝炎病毒(HAV)不经血液制品传播.因为:(1)HAV极少经血液传播;(2)在献血员群体中极少见到HAV血症;(3)制备血液制品的混合血浆中存在大量抗-HAV.然而,1989～1994年间,许多国家相继报道了因输用经溶剂/去污剂处理的因子Ⅷ浓制剂感染HAV的病例.本文对两例血友病乙患者因于1985年接受同一批因子Ⅸ浓制剂(未经加热处理,应用离子交换纯化的凝血酶原复合物,批号为90742)治疗而于治疗50天内发生甲型肝炎的病例进行回顾性研究.抽取该厂家1982～1986年间生产的批号90742和其前后生产的共26批制品,采用逆转录-聚合酶链反应检测HAV RNA.
Hepatitis A virus (HAV) has long been thought to be non-transmissible through blood products because: (1) HAV is rarely transmitted by blood; (2) HAV is rarely seen in blood donor populations; (3) However, a large number of anti-HAVs were found in the mixed plasma of the preparation of blood products.However, many cases of HAV infection by solvent / detergent-treated factor VIII were reported in many countries from 1989 to 1994. In this paper, Yushi B patients were retrospectively treated for Hepatitis A occurring within 50 days of treatment due to treatment with the same batch of Factor IX concentrate (Unglazed, ion exchange purified prothrombin complex, Lot 90742) in 1985 A total of 26 batches of products produced by the manufacturer between 1982 and 1986, batch number 90742 and before and after production were extracted and HAV RNA was detected by reverse transcription-polymerase chain reaction.