Spontaneous regression of pituitary macroadenomas israre.It is generally thought that absorption of thenecrotic tissue after pituitary apoplexy may cause thespontaneous healing of the tumor.However,such casesare often accompanied by hypopituitarism,which souldbe treated with hormone replacement therapy.Here wereport two cases of spontaneous remission of pituitarymacroadenomas in women,who had complete tumordisappearance with preserved pituitary function. Spontaneous regression of pituitary macroadenomas israre. It is generally thought that absorption of thenecrotic tissue after pituitary apoplexy may cause thespontaneous healing of the tumor. Host, such casesare often accompanied by hypopituitarism, which sbebe treated with hormone replacement therapy. Here wereport two cases of spontaneous remission of pituitarymacroadenomas in women, who had complete tumordisappearance with preserved pituitary function.