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目的:检测原因不明习惯性流产(UHA)患者免疫治疗前后血清中表皮生长因子(EGF)水平变化,探讨其变化在UHA发病及治疗中的作用。方法:采用皮下注射丈夫淋巴细胞的方法治疗UHA患者;应用ELISA法检测正常非孕妇女30例和UHA妇女30例免疫治疗前后血清EGF水平变化(Pg/mL)。结果:UHA患者血清中EGF水平(107.5±47.9)明显低于正常非孕妇女(169.1±56.6),P<0.01;免疫治疗后EGF水平(152.3±63.9),比治疗前明显升高,P<0.01。结论:血清EGF水平降低可能与UHA的发生相关,免疫治疗可上调UHA患者血清中EGF水平,利于胎盘胎儿生长,使妊娠成功。
OBJECTIVE: To detect the changes of serum epidermal growth factor (EGF) levels in patients with unexplained habitual abortion (UHA) before and after immunotherapy and to explore the role of these changes in the pathogenesis and treatment of UHA. Methods: UHA patients were treated subcutaneously with her husband’s lymphocytes. Serum levels of EGF (Pg / mL) were measured before and after immunotherapy in 30 normal pregnant women and 30 UHA women by ELISA. Results: The level of EGF in serum of patients with UHA (107.5 ± 47.9) was significantly lower than that of normal non-pregnant women (169.1 ± 56.6), P <0.01. The level of EGF in serum of patients with UHA (152.3 ± 63.9) was significantly higher than that before treatment, P < 0.01. Conclusion: The decrease of serum EGF level may be related to the occurrence of UHA. Immunotherapy can increase the level of EGF in serum of UHA patients, which is good for the growth of fetal fetus and the success of pregnancy.