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目的:探究脑苷肌肽对新生儿缺氧缺血性脑病的临床疗效及安全性。方法:收集我院收治的缺氧缺血性脑病患儿61例,根据治疗方法不同分为实验组与对照组,实验组31例采用脑苷肌肽治疗,对照组30例采用胞二磷胆碱治疗。观察并比较两组患儿的治疗效果及不良反应情况。结果:治疗后,两组患儿惊厥、嗜睡以及过度兴奋等神经症状均逐渐消失,且实验组明显早于对照组,差异具有统计学意义(P<0.05);与治疗前相比,两组治疗后行为能力、肌张力、原始反应以及意识状态水平均明显升高,且治疗10-14天后,实验组新生儿行为学评分显著高于对照组,差异具有统计学意义(P<0.05);两组不良反应比较,差异无统计学意义(P>0.05)。结论:脑苷肌肽治疗新生儿缺氧缺血性脑病可有效减轻缺血所致的神经功能障碍,加速神经损伤恢复,临床疗效显著,且安全性较高。
Objective: To investigate the clinical efficacy and safety of encephalosidein in neonatal hypoxic-ischemic encephalopathy. Methods: Totally 61 children with hypoxic-ischemic encephalopathy admitted to our hospital were divided into experimental group and control group according to different treatment methods. 31 cases in experimental group were treated with cerebroside, 30 cases in control group were treated with citicoline treatment. Observe and compare the treatment effect and adverse reaction of two groups of children. Results: After treatment, the neurological symptoms such as convulsion, drowsiness and hyperexcitability gradually disappeared, and the experimental group was earlier than the control group, the difference was statistically significant (P <0.05); compared with before treatment, two groups After treatment, the behavior, muscle tone, initial response and the level of consciousness were significantly increased. After 10-14 days of treatment, the newborn behavioral score of the experimental group was significantly higher than that of the control group (P <0.05). Adverse reactions between the two groups, the difference was not statistically significant (P> 0.05). Conclusion: The treatment of neonatal hypoxic-ischemic encephalopathy with encephalon glycosides can effectively alleviate the neurological dysfunction induced by ischemia and accelerate the recovery of nerve injury. The clinical effect is significant and safe.