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目的：深入了解侵袭性垂体腺瘤的生物学特性，以提高其诊断、治疗水平。万法：对54例病人（非侵袭性垂体腺瘤31例，侵袭性垂体腺瘤23例）的临床、病理、细胞动力学三方面资料作差异显著性检验及相关性分析。结果：在临床表现方面，两组病人在病程，肿瘤大小，肿瘤组织坏死、卒中、囊变发生率，手术全切除率，术后复发率方面有显著差异（P＜0．05）。病理学方面，两组在微血管定量方面有显著差异（P＜0．05）。细胞动力学的研究显示：侵袭性垂体腺癌的细胞增殖速率显著大于非侵袭性腺瘤（P＜0．01）。结论：侵袭性垂体腺瘤临床进展快，多为大腺瘤，肿瘤组织坏死、囊变、卒中发生率高，手术全切除率低，术后易复发，肿瘤血供较为丰富，肿瘤细胞增殖较快。
Objective: To understand the biological characteristics of invasive pituitary adenomas in order to improve their diagnosis and treatment. Wanfa: The clinical, pathological, and cellular dynamics of 54 patients (31 non-invasive pituitary adenomas and 23 invasive pituitary adenomas) were tested for significant differences and correlation analysis. Results: In terms of clinical manifestations, there were significant differences in the course of disease, tumor size, necrosis of tumor tissue, incidence of stroke, cystic degeneration, total resection rate, and postoperative recurrence rate between the two groups (P<0.05). In terms of pathology, there was a significant difference in microvascular quantification between the two groups (P<0.05). The study of cell dynamics showed that the proliferation rate of invasive pituitary adenocarcinoma was significantly greater than that of non-invasive adenoma (P<0.01). Conclusion: The clinical progress of invasive pituitary adenoma is rapid. Most of them are large adenomas. The incidence of necrosis, cystic degeneration and stroke in tumor tissue is high. The total resection rate is low, and postoperative recurrence is easy. The tumor blood supply is more abundant and the tumor cell proliferation is more fast.