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采用整群抽样方法，选择了１０１８名１～７岁新生儿期接种３针１０μｇ乙型肝炎血源疫苗免疫的儿童，检测ＨＢｓＡｇ、抗ＢＨｓ和抗ＨＢｃ，以评价乙肝疫苗纳入儿童计划免疫，实施低剂量免疫策略７年后的效果。结果显示ＨＢｓＡｇ阳性率为２．０％，与１９８５年该免疫计划实施前儿童ＨＢｓＡｇ阳性率１２．７％比较，疫苗保护率为８５．０％，保护率从免疫后１～２年的８２．０％逐年上升为免疫后７年的９６．４％；抗ＨＢｓ阳性率为７９．７％，保护性抗体阳性率为５４．２％；两者从免疫后１～２年的９１．８％和７５．０％明显下降为免疫后第７年的７３．７％和４８．２％；抗ＨＢｃ阳性率为３．０％，显著低于免疫前的１８．４％。结果说明低剂量免疫策略控制乙肝是成功的，实施７年后是否需加强免疫有待进一步观察。
A total of 1018 children aged 1 to 7 years old were enrolled in this study. Children immunized with 3 doses of 10μg Hepatitis B vaccine were tested for HBsAg, anti-BHs and anti-HBc to evaluate the planned immunization for hepatitis B vaccine in children Effect of low dose immunization strategy after 7 years. The results showed that the positive rate of HBsAg was 2.0%. Compared with 12.7% of children before the implementation of the immunization program in 1985, the vaccine protection rate was 85.0% and the protection rate was 1-2 years after immunization. 0% increased year by year to 96.4% after 7 years of immunization; the positive rate of anti-HBs was 79.7%, the positive rate of protective antibody was 54.2%; both from 91.8% And 75.0% decreased significantly to 73.7% and 48.2% of the seventh year after immunization. The positive rate of anti-HBc was 3.0%, which was significantly lower than 18.4% before immunization. The results show that low-dose immunization strategy to control hepatitis B is successful, the implementation of seven years after the need to strengthen the immune remains to be further observed.